Keywords
HIV
central nervous system
chemotherapy
flow cytometry
How to Cite
Abstract
Burkitt lymphoma (BL) is a very aggressive form of B-cells neoplasm that accounts for about 1%-5% of all non-Hodgkin lymphomas. The World Health Organization classifies BL into three clinical groups: endemic, sporadic and immunodeficiency related. High-intensity chemotherapy regimens have improved the overall survival of BL patients, and thus, current therapeutic ecommendations offered by the National Comprehensive Cancer Network include multi-drug regimens with CNS prophylaxis. Immunohistochemistry tests and cytogenetic studies that play an important role in the diagnosis and treatment of BL are recommended. The presented case aims to describe the management of a patient diagnosed with HIV-associated BL with nervous system involvement. Tissue biopsies of the mesenteric and right maxillary region masses, laboratory tests, CT scans, bone marrow aspiration and biopsy, and cerebrospinal fluid analysis were performed as diagnostic tools. 6 cycles of R-hyper-CVAD chemotherapy regimen were used, along with high-activity antiretroviral therapy and intrathecal chemotherapy, reaching complete remission.
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