Sea-blue histiocyte syndrome in bone-marrow secondary to total parenteral nutrition. A case report.
Vol. 27 No. 2 (2023), Discussion
Vol. 27 No. 2 (2023)

Sea-blue histiocyte syndrome in bone-marrow secondary to total parenteral nutrition. A case report.

Discussion
https://doi.org/10.48057/hematologa.v27i2.519
Published 2023-09-28
D Fernández
Servicio de Hematología- Hospital Nacional Profesor Alejandro Posadas, Buenos Aires, Argentina.
D Maymó
Servicio de Hematología- Hospital Nacional Profesor Alejandro Posadas, Buenos Aires, Argentina.
G Alfonso
Servicio de Hematología- Hospital Nacional Profesor Alejandro Posadas, Buenos Aires, Argentina.
Revista Hematología
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Keywords

bone marrow
sea-blue histiocytosis syndrome
parenteral nutrition
pancytopenia

How to Cite

Fernández, D., Maymó, D., & Alfonso, G. (2023). Sea-blue histiocyte syndrome in bone-marrow secondary to total parenteral nutrition. A case report. Journal of Hematology, 27(2), 44–48. https://doi.org/10.48057/hematologa.v27i2.519
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Abstract

The sea-blue histiocyte was first described in 1947 in a splenic aspirate(1). They are macrophages laden with phospholipid granules that stain dark blue with the May-Grünwald-Giemsa stain. These granules result from lysosomal accumulation of indigestible oxidized lipid or lipoprotein material(2). They can occur in a wide variety of hematological conditions and in different metabolic disorders such as Niemann-Pick syndrome or Gaucher disease(3,4). Sea-blue histiocyte syndrome presents with hepatosplenomegaly and/or Pancytopenia due to accumulation of blue histiocytes in bone marrow and/or liver(4). It corresponds to a rare entity. Here we present a case report associated with parenteral nutrition.

https://doi.org/10.48057/hematologa.v27i2.519
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