Acute basophilic leukemia. Case report
Vol. 21 No. 1 (2017), Imaging in Hematology
Vol. 21 No. 1 (2017)

Acute basophilic leukemia. Case report

Imaging in Hematology
Published 2019-04-27
L Galelli
U.A. Por + Salud Dr. Cesar Milstein.
A Starc
U.A. Por + Salud Dr. Cesar Milstein
N Carrara
U.A. Por + Salud Dr. Cesar Milstein
G Scoles
U.A. Por + Salud Dr. Cesar Milstein.
ISSN 2250-8309 (versión en línea) - ISSN 0329-0379 (versión impresa)
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Keywords

acute basophilic leukemia, toluidine blue, metachromatic reaction

How to Cite

Galelli, L., Starc, A., Carrara, N., & Scoles, G. (2019). Acute basophilic leukemia. Case report. Journal of Hematology, 21(1), 100–103. Retrieved from https://www.revistahematologia.com.ar/index.php/Revista/article/view/142
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Abstract

Acute basophilic leukemia (WHO-Classification 2008-Acute myeloblastic leukemia-NOS) is a rare disease that represents less than 1% of all the cases of acute myeloblastic leukemia. We report the case of a 70 year old man, who presented weight loss, massive splenomegaly and 90.000 leukocytes/ mm3, with 80% of blasts of medium size and low number of granules. Cytochemistry reactions were negative for peroxidase and Naphtol AS D Esterase, and weakly positive for periodic acid–Schiff. Bone marrow’s immuno - phenotype didn’t allow lineage assignment: lymphoid markers were negative, HLADR++; CD13-/+; CD33-/+; CD34++; CD123+/++. Translocation t(9;22) was negative. A tolouidine blue staining showed a positive metachromatic reaction, allowing thus a diagnosis of acute leukemia with basophilic differentiation.

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